Symptoms of OA are pain, swelling, and gradual loss of motion of the joint. The lifetime risk for symptomatic knee OA is 44.7% in the general population with increasing age, female sex, and obesity being the primary risk factors for developing the condition.
Conventional management of the condition involves use of non-steroidal anti-inflammatory drugs, joint injections of glucocorticoids, hyaluronic acid etc. In advanced cases joint replacement/surgical management may be indicated. However, the overall response and prognosis to the above mentioned treatment modalities remain unsatisfactory.
Mesenchymal progenitor cells have been shown to have immunoregulatory, antiinflammatory and tissue repairing properties. Treatment with these cells is a feasible, safe, and promising treatment modality for patients with OA.
Our protocol involves harvesting cells from the patients own body (autologous stem cells). After activation the cells are transplanted into the appropriate site. The degree of improvement achieved will depend on the stage of the condition, presence of other influencing factors and patient compliance with respect to following diet and allied therapies (physiotherapy, yoga).
Sixty-five years old Mr. Visaria had complains of pain in both his knees which would aggravate on standing. I was unable to walk with ease and climb stairs, the way I could before the pain began, says the patient. His deteriorating condition led to difficulty in performing daily activities. He adds, Being a business person, my work requires me to move around often. The pain was causing limitations in that as well. He was prescribed medications for pain and physiotherapy exercises, but ultimately was advised joint replacement stating the severity of the condition in both knees.
This is a case of Osteoarthritis (OA), which is a degenerative joint disease that causes cartilage loss and morphological damage to joint tissues. The condition is common in the general population (lifetime risk of 44.7%) with increasing age and obesity being the contributing risk factors.
Mr. Visaria is also diabetic and the doctors had mentioned that due to this associated condition, his general healing potential may be reduced. This made the patient reluctant to undergo joint replacement procedure because of the surgery involved. I was not sure if I would recover completely from the procedure, hence decided to look for more advanced treatment options, says Mr. Visaria. Through a relative of his, Mr. Visaria learnt about cellular therapy and decided to contact Our clinical team at Hospital.
Conventionally, pain relief medications, joint injections with steroids and/or lubricating agents are advised for treatment of OA. In advanced cases joint replacement/surgical management may be indicated, says Doctor. He adds that, These forms of treatment only symptomatically treat the condition and are ineffective in preventing the condition from worsening. According to Doctor, autologous cellular therapy with mesenchymal stem cells (MSC) utilizes the bodys own potential to repair the damage. He continues, As it is rapidly being proven through research, the multi-differentiation potential of stem cells is effective in treating various conditions. These cells have immune-regulatory, anti-inflammatory and tissue repairing properties. Thus, treatment with these cells is a non-invasive, safe, and promising treatment modality for patients with OA. Additionally, presence of co-morbid conditions does not affect the outcome of cellular therapy. In fact, multiple conditions can be treated simultaneously, given the varied properties of MSCs, opines Doctor.
Mr. Visaria underwent 2 sessions of cellular therapy at Hospital. He had relief in pain within 2-3 days of the 1st procedure. Follow-up was done 1 month after the 1st procedure wherein clinical assessment was done. The patient showed improvement in range of movement and further reduction in pain intensity. The decision to perform 2nd session of therapy was made following X-ray investigation in the 3rd month. This patient requires more number of sessions of cellular therapy as radiographic findings suggest extensive damage of both knee joints. Our initial goal through cellular therapy was to arrest the progression of the condition to prevent further deterioration and later to possibly achieve regeneration in the affected area, says Doctor.
Additional therapeutic modalities of physiotherapy, yoga, diet and nutraceuticals specific to the patients condition were also advised. Through autologous cellular therapy and a personalized treatment protocol for every patient, we are harnessing the power of endogenous stem cells to address the root cause of conditions rather than palliative management of symptoms, says Doctor.
Mr. Visaria concludes happily, I can now walk comfortably without pain and have been told that I will not require joint replacement surgery, which is what I wanted to avoid. My blood glucose level is also under control, which is an added benefit.