For bone healing to happen, the bone needs adequate stability and blood supply. Good nutrition also plays a role in bone healing.
Nonunions happen when the bone lacks adequate stability, blood flow, or both. They also are more likely if the bone breaks from a high-energy injury, such as from a car wreck, because severe injuries often impair blood supply to the broken bone.
Risk Factors Several factors increase the risk of nonunion. Use of tobacco or nicotine in any form (smoking, chewing tobacco, and use of nicotine gum or patches) inhibits bone healing and increase the chance of a nonunion Older age Severe anemia Diabetes A low vitamin D level Hypthyroidism Poor nutrition Medications including anti-inflammatory drugs such as aspirin, ibuprofen, and prednisone. The physician and patient should always discuss the risks and benefits of using these medications during fracture healing Infection A complicated break that is open or compound